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Moderate chronic ingestion, eg, 4 g/day, usually leads to transient mild elevation of liver enzymes in healthy individuals 12 but can in rare cases cause acute liver failure

This genetic influence is a key reason for its wide-ranging benefits

45,46 Increasingly, more studies have shown that G6PD activity is increased in several types of cancers, including bladder, breast, prostate, gastric cancers compared with normal tissues, and the high expression of G6PD predicts poor clinical outcome in various cancer patients and plays critical roles in tumorigenesis and chemoresistance